Temperature Effect on IgE Binding to CD23 Versus Fc RI
نویسندگان
چکیده
منابع مشابه
Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc«RI): role in asthma
Polymorphonuclear neutrophils (PMNs) are important effector cells in host defense and the inflammatory response to antigen. The involvement of PMNs in inflammation is mediated mainly by the Fc receptor family, including IgE receptors. Recently, PMNs were shown to express two IgE receptors (CD23/Fc«RII and galectin-3). In allergic diseases, the dominant role of IgE has been mainly ascribed to it...
متن کاملEpidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI
Human epidermal Langerhans cells (LC) bearing IgE are found in disease states associated with hyperimmunoglobulinemia E. When studying the mechanism(s) underlying this phenomenon, immunohistology revealed that a majority of epidermal LC from normal skin of healthy individuals can specifically bind monomeric IgE. IgE binding to LC could neither be prevented by preincubation of the tissue with mo...
متن کاملThe binding site on human immunoglobulin E for its high affinity receptor.
Immunoglobulin (Ig) E antibodies mediate allergic responses by binding to specific high affinity receptors, Fc epsilon RI, on mast cells and basophils. Previous studies have shown that the principal Fc epsilon RI binding site is located on the third constant domain, Fc epsilon 3, of IgE. Based on a model of the IgE Fc epsilon 3 (which is homologous to the second constant domain of IgG), homolog...
متن کاملLack of Fc-e Receptors on Murine Eosinophils: Implications for the Functional Significance of Elevated IgE and Eosinophils in Parasitic Infections
Chronic infection with Schistosoma mansoni induces in huor the transcription of Fc-e receptors (Fc-e RI, Fc-e RII/CD23). To investigate normal murine eosinophils, we cultured normans and mice a Th2-dominant immune response in which eosinophils and IgE are conspicuously elevated. Human eomal mouse bone marrow cells with recombinant IL-3, recombinant IL-5, and recombinant granulocyte-macrophage c...
متن کاملExpression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals
Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and that functional events occurring after cross-linking of membrane-bound IgE on these cells are medi...
متن کامل